Copeptin in liver Cirrhosis: A review article

Liver cirrhosis represents the advanced stage of all chronic liver diseases, marked by tissue fibrosis and the formation of irregular structural nodules. Copeptin, a 39-amino-acid glycopeptide with no fully defined physiological role, is co-synthesized with vasopressin, also known as the antidiuretic hormone, and directly reflects vasopressin levels. As an alternative marker for vasopressin, copeptin is both practical and valuable in assessing hemodynamic instability and prognosis in cirrhosis. This study examines the relationship between copeptin and liver cirrhosis, highlighting its potential as a predictive diagnostic tool for evaluating cirrhosis severity and its complications. Copeptin demonstrates high sensitivity and specificity in predicting hepatorenal syndrome (HRS) in advanced cirrhosis. Moreover, incorporating serum copeptin levels into the Child-Turcotte-Pugh score may enhance the assessment of disease progression. Additionally, copeptin could be useful in monitoring cirrhosis and anticipating its common complications.