IRON DEFICIENCY ANEMIA INFLUENCE ON DIABETIC INDIVIDUALS'HbA1c: CLINICAL AND HEMATOLOGICAL FINDINGS
The purpose of our research is to assess the impact of iron deficient anemia on the HbA1c, clinical, and hematological outcomes of diabetes patients in Pakistan and Bangladesh. Researchers from multiple settings in Bangladesh and Pakistan participated in the four-month cross-sectional study, which took place in the Department of Pathology/Hematology at Ayub Medical College in Abbottabad, Pakistan, between December 2023 and March 2024. A straightforward sampling procedure was used to determine the population size, with 174 patients participating in the study. The structured surveys were used to gather clinical data as well as socio-demographic traits. Hematologic characteristics were gathered. Hematology analyzers performed CBCs, analyzers measured HbA1cs, and biochemistry analyzers assessed serum ferritin levels. The relationship between hematological markers and HbA1c was ascertained using Pearson's Chi-square test. To compare the patients' HbA1c and hematological characteristics, a t-test without significance was computed. P-values less than 0.05 were considered statistically significant. Out of the 174 participants in the study, 87 were from Pakistan and the remaining 87 were from Bangladesh. Out of the total population, 48.2% of people were men and 51.8% were women. The study population comprised 63/174 individuals aged 26-35. For all research settings, all hematological parameters, serum ferritin, and HbA1c were assessed. Significant differences were seen in the mean RBC, HCT, MCV, MCH, MCHC, and HbA1c (P < 0.05). With RBC, MCV, MCH, and MCHC, HbA1C was statistically not significant (p > 0.05). As a result of this study, patients with IDA from Bangladesh had considerably lower HbA1c values than those from Pakistan. Because these patients' true HbA1clevelsl may be lower than the reported value, employing HbA1c to monitor them may be misleading. It is advised to do a thorough analysis with lots of individuals using cutting-edge laboratory methods.